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Study: Diet plays role in colon cancer recurrence

Thursday November 8, 2012
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Colon cancer survivors whose diet is heavy in complex sugars and carbohydrate-rich foods are far more likely to have a recurrence of the disease than are patients who eat a better balance of foods, according to a study.

The connection especially is strong in patients who are overweight or obese, reported researchers with the Dana-Farber Cancer Institute. More than 1,000 patients with stage III colon cancer participated in the study, one of the first to examine how diet can affect the chances that the disease will recur.

"Our study certainly supports the idea that diet can impact the progression of colon cancer, and that patients and their doctors should consider this when making post-treament plans," Jeffrey Meyerhardt, MD, MPH, the study’s lead author, said in a news release. "But further research is needed to confirm our findings."

Recent studies have shown that colorectal cancer survivors whose diet and activity patterns lead to excess amounts of insulin in the blood have a higher risk of cancer recurrence and death from the disease. High insulin levels can be produced by eating too many starchy and sugar-laden foods.

In a previous study of advanced-stage colon cancer patients, Meyerhardt and his colleagues found that those with a typical "Western" diet — marked by high intakes of meat, fat, refined grains and sugary desserts — were three times more likely to have a cancer recurrence than those whose diets were least Western.

The new study was conducted to explore which component of the Western diet is most responsible for the increased risk of recurrence. It involved 1,011 stage III colon cancer patients who had undergone surgery and participated in a National Cancer Institute-sponsored Cancer and Leukemia Group B clinical trial of follow-up chemotherapy for their disease. Participants reported their dietary intake during and six months after the trial.

Researchers tracked the patients’ total carbohydrates, as well as their glycemic index and glycemic load, and looked for a statistical connection between these measures and the recurrence of colon cancer.

They found that participants with the highest dietary levels of glycemic load and carbohydrate intake had an 80% increased risk of colon cancer recurrence or death compared with those who had the lowest levels. Among patients who were overweight or obese (body mass index above 25 kg/m2), the increase was even greater.

"In light of the latest and previous research, we theorize that factors including a high glycemic load may stimulate the body’s production of insulin," Meyerhardt said. "That, in turn, may increase the proliferation of cells and prevent the natural cell-death process in cancer cells that have metastasized from their original site."

Meyerhardt added that while the study does not prove diets high in glycemic load and carbohydrate intake cause recurrence of colon cancer, the results strongly suggest that such factors play a role. "Our findings may offer useful guidance for patients and physicians in ways of improving patient survival after treatment," he said.

The study appeared Nov. 7 on the website of the Journal of the National Cancer Institute. The study abstract is available at http://jnci.oxfordjournals.org/content/early/2012/11/02/jnci.djs399.abstract.


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