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Study: Metformin may help ovarian cancer patients

Monday December 3, 2012
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The common diabetes medication metformin may be considered for use in the prevention or treatment of ovarian cancer, according to a study.

Ovarian cancer patients who took the drug tended to live longer than patients who did not take it, Mayo Clinic researchers reported Dec. 3 on the website of the journal Cancer.

New treatments are desperately needed for ovarian cancer, according to background information in the study. Previous research has indicated that metformin, which originates from the French Lilac plant, may have anticancer properties. To look for an effect of the medication in ovarian cancer, Viji Shridhar, PhD, Sanjeev Kumar, MD, both of the Mayo Clinic in Rochester, Minn., and their colleagues analyzed information from 61 patients with ovarian cancer who took metformin and 178 patients who did not.

Of those who took metformin, 67% had not died from ovarian cancer within five years, compared with 47% of those who did not take the medication. After accounting for factors such as cancer severity and patients’ body mass index, the investigators found that patients taking metformin were 3.7 times more likely to survive throughout the study than those not taking it.

The findings demonstrate only a correlation between metformin intake and better survival, and additional studies are needed to decipher whether the observations truly represent a beneficial effect of metformin in patients with ovarian cancer, the researchers said.

"This study opens the door for using metformin in large-scale randomized trials in ovarian cancer which can ultimately lead to metformin being one option for treatment of patients with the disease," Shridhar said in a news release. Such trials are underway for patients with breast cancer.

The study abstract is available at http://onlinelibrary.wiley.com/doi/10.1002/cncr.27706/abstract.


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