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Atrial fibrillation may be linked to cognitive decline

Thursday June 6, 2013
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People who develop atrial fibrillation may also be more likely to develop problems with memory and thinking, according to a study.

“Our study shows that on average, problems with memory and thinking may start earlier or get worse more quickly in people who have atrial fibrillation,” study author Evan L. Thacker, PhD, of the University of Alabama at Birmingham, said in a news release. “This means that heart health is an important factor related to brain health.”

The study, published June 5 on the website of Neurology, the medical journal of the American Academy of Neurology, involved people 65 and older from four communities in the United States who were enrolled in the Cardiovascular Health Study.

Participants did not have a history of atrial fibrillation or stroke at the start of the study. They were followed for an average of seven years and received a 100-point memory and thinking test every year. People who had a stroke were not included in this analysis after the stroke. Of the 5,150 participants, 552, or about 11%, developed atrial fibrillation during the study.

People with atrial fibrillation were more likely to experience lower memory and thinking scores at earlier ages than people with no history of atrial fibrillation, the researchers found. For example, from age 80 to age 85 the average score on the 100-point test went down by about six points for people without atrial fibrillation and by about 10 points for people with atrial fibrillation.

Among participants ages 75 and older, the average rate of decline was about three to four points faster per five years of aging with atrial fibrillation than without. “This suggests that on average, people with atrial fibrillation may be more likely to develop cognitive impairment or dementia at earlier ages than people with no history of atrial fibrillation,” Thacker said.

Thacker noted that scores below 78 points on the 100-point test are suggestive of dementia. People without atrial fibrillation in the study were predicted on average to score below 78 points at age 87, while people with atrial fibrillation were predicted to score below 78 points at age 85.

“If there is indeed a link between atrial fibrillation and memory and thinking decline, the next steps are to learn why that decline happens and how we can prevent that decline,” Thacker said.

The study was supported by the National Heart, Lung, and Blood Institute, the National Institute of Neurological Disorders and Stroke and the National Institute on Aging.

Read the study abstract: www.neurology.org/content/early/2013/06/05/WNL.0b013e31829a33d1.abstract.


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