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Pre-pregnancy diabetes linked to MRSA infection risk

Wednesday July 3, 2013
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Women with pre-pregnancy diabetes are more than three times as likely as mothers without diabetes to become infected with methicillin-resistant Staphylococcus aureus before hospital discharge, according to a study.

The aim of the study — published in the July issue of the American Journal of Infection Control, the official publication of the Association for Professionals in Infection Control and Epidemiology — was to investigate the extent to which pre-pregnancy and gestational diabetes are associated with MRSA infection.

Researchers from UCLA found that pre-pregnancy diabetes was associated with more than triple the risk of MRSA following delivery, but found no association between MRSA and gestational diabetes.

The researchers analyzed more than 3.5 million delivery-related hospital admissions from the Nationwide Inpatient Sample, a system that accounts for 20% of community hospitals in the United States. Of these admissions, 5.3% of mothers (185,514 women) were diagnosed with gestational diabetes, and nearly 1% (28,939) had pre-pregnancy diabetes.

The researchers identified 563 cases of invasive MRSA among the mothers following delivery. To the extent that infection site information was available, the most frequent sources of infection were skin (30.9%), urinary tract (6.4%), other genitourinary sites (5.2%), wound infections (3%) and septicemia (2%).

"When combined with previous research showing increased risk of certain infections in diabetic persons, it seems likely that diabetic women are at increased risk of MRSA infection compared with other women admitted for delivery of an infant," the authors wrote.

"As we wait for further research on this topic, it might seem prudent for hospitals to be vigilant about possible MRSA risk among diabetic women in labor and delivery."

Read the study: http://www.ajicjournal.org/article/S0196-6553%2812%2901340-5/fulltext.


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