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Restless legs syndrome linked to death risk in men


Men who experience restless legs syndrome may have a higher risk of dying earlier, according to a study.

The disorder is characterized by an irresistible urge to move the legs and often causes leg sensations of burning, creeping and tugging, which usually are worse at night, according to an American Academy of Neurology news release.

“RLS affects 5% to 10% of adults across the country,” study author Xiang Gao, MD, PhD, of the Harvard School of Public Health, Harvard Medical School and the Channing Division of Network Medicine at Brigham & Women’s Hospital in Boston, said in a news release. “Our study highlights the importance of recognizing this common but underdiagnosed disease.”

For the study, published June 12 on the website of Neurology, the medical journal of the AAN, 18,425 men with an average age of 67 who did not have diabetes, arthritis or kidney failure were evaluated for RLS. A total of 690 of the men, or 3.7%, met the criteria for RLS at the beginning of the study. Information about major chronic diseases was collected every two years.

During the eight years of study follow-up, 2,765 participants died. Of the people with RLS, 171, or 25%, died during the study, compared with 594, or 15%, of those who did not have RLS.

The researchers calculated that men with RLS had a nearly 40% increased risk of death compared with men without RLS. The association dropped only slightly after adjusting for factors such as body mass index, lifestyle, chronic conditions, lack of sleep and other sleep disorders. When the researchers excluded people with major chronic conditions such as cancer, heart disease and hypertension from the analysis, the association between RLS and an increased risk of death rose to 92% higher than those without RLS.

“We found that the increased risk was not associated with the usual known risk factors, such as older age, being overweight, lack of sleep, smoking, being physically inactive and having an unhealthy diet,” Gao said. “The increased mortality in RLS was more frequently associated with respiratory disease, endocrine disease, nutritional/metabolic disease and immunological disorders. Through research, we need to pinpoint why and how RLS leads to this possible higher risk of dying early.”

Although RLS can occur in children, the study did not assess whether there was a long-term risk in this population.

Read the study abstract:


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