Data indicate a rise in the prevalence of chronic kidney disease among people ages 80 and older, and suggest efforts to address CKD among the oldest old may be necessary, according to researchers.
The finding was published in a research letter in the Sept. 25 issue of the Journal of the American Medical Association.
Recent studies have shown that older adults with CKD defined as an estimated glomerular filtration rate of less than 60 mL/min/1.73 m2 have a high prevalence of concurrent complications and increased risk for adverse outcomes including mortality, cardiovascular disease and kidney failure. A prior study demonstrated an increase in CKD prevalence between 1988-1994 and 1999-2004 for the general U.S. population.
However, trends in CKD prevalence have not been reported for the oldest old, defined as those ages 80 and older, wrote C. Barrett Bowling, MD, MSPH, of the Veterans Affairs Medical Center in Atlanta at the time of the study, and colleagues.
The authors used data from national surveys the National Health and Nutrition Examination Surveys 1988-94 and 1999-2010 to study 3,558 participants ages 80 and older who completed a medical evaluation in the NHANES mobile examination center.
The authors found that the prevalence of an estimated GFR of less than 60 mL/min/1.73 m2 was 40.5% in 1988-94, 49.9% in 1999-2004, and 51.2% in 2005-10.
The prevalence of a more severe reduction in estimated GFR (less than 45 mL/min/1.73 m2) was 14.3% in 1988-94, 18.6% in 1999-2004 and 21.7% in 2005-10.
Study access (via subscription or purchase): http://jama.jamanetwork.com/article.aspx?articleid=1741807