Giving an infant a probiotic during the first three months of life appears to reduce the onset of gastrointestinal disorders and result in lower associated costs, according to an Italian study.
Infant colic, acid reflux and constipation are the most common gastrointestinal disorders that lead to a pediatrician referral during the first six months of life, according to background information in the study, which was published Jan. 13 on the website of JAMA Pediatrics. Those disorders often are responsible for hospitalization, feeding changes, use of drugs, parental anxiety and loss of parental working days.
Flavia Indrio, MD, of the Aldo Moro University of Bari, Italy, and colleagues randomized 554 newborns in nine pediatric units in Italy to the probiotic Lactobacillus reuteri DSM 17938 or placebo for 90 days, and asked parents to record in diary entries the number of vomiting episodes and evacuations, the duration of inconsolable crying and the number of pediatrician visits. Change in daily crying time, vomiting, constipation and the cost benefits of probiotic supplement use were measured during the three-month period.
At three months of age, the average duration of crying time (38 vs. 71 minutes), regurgitations (2.9 vs. 4.6) and evacuations per day (4.2 vs. 3.6) differed in the probiotic and placebo groups, respectively. Probiotic use also was associated with a nearly $119 average savings per patient in each family.
Driving a change of colonization during the first weeks of life through giving lactobacilli may promote an improvement in intestinal permeability, visceral sensitivity and mast cell density, the authors wrote, adding that probiotic administration may represent a new strategy for preventing these conditions, at least in predisposed children.