Scientists from China have reported on the worlds first confirmed case of human infection with a new avian influenza A H10N8 virus in a 73-year-old woman who died from the infection.
Tests on tracheal swab samples established that the virus was a new genetic reassortment avian-origin H10N8 virus (JX346), the researchers reported Feb. 4 on the website of The Lancet. Whole genome sequencing indicated that all the genes of the virus were of avian origin, with six internal genes derived from avian H9N2 viruses that are circulating in poultry in China.
A genetic analysis of the H10N8 virus shows a virus that is distinct from previously reported H10N8 viruses, having evolved some genetic characteristics that may allow it to replicate efficiently in humans, Yuelong Shu, PhD, of the Chinese Center for Disease Control and Prevention in Beijing, said in a news release.
Notably, H9N2 virus provided the internal genes not only for the H10N8 virus, but also for H7N9 and H5N1 viruses.
The woman, from Nanchang City in China, presented to hospital with fever and severe pneumonia on Nov. 30. Despite antibiotic and antiviral treatment she deteriorated rapidly, developed multiple organ failure and died nine days later.
The results suggest JX346 might originate from multiple reassortments between different avian influenza viruses, Shu said. The H10 and H8 gene segments might have derived from different wild bird influenza viruses reassorted to give rise to a hypothetical H10N8 virus in wild birds, which infected poultry and then reassorted with H9N2 viruses in poultry to give rise to the novel reassortant JX346 (H10N8) virus.
Importantly, the virus had a mutation in the PB2 gene that is believed to be associated with increased virulence and adaption in mammals, and could enable the virus to become more infectious to people, co-investigator Qi Jin, MD, PhD, from the Chinese Academy of Medical Sciences and Peking Union Medical College in Beijing, said in the news release.
Further investigation revealed the woman had visited a live poultry market a few days prior to infection, suggesting the incubation time was about four days, similar to other avian influenza virus infections. However, no H10N8 virus was found in samples collected from the poultry site the patient visited, and the source of the infection remains unknown.
The H10N8 strain was previously isolated from a water sample taken from Chinas Dongting Lake in Hunan Province in 2007 and detected at a live poultry market in Guangdong province in 2012. But human infection with an N8 subtype had not been reported.
Study abstract: http://bit.ly/MXxJbB