Older people who have apathy but not depression may have smaller brain volumes than those without apathy, according to a study.
Just as signs of memory loss may signal brain changes related to brain disease, apathy may indicate underlying changes, Lenore J. Launer, PhD, with the National Institute on Aging at the National Institutes of Health in Bethesda, Md., and a member of the American Academy of Neurology, said in a news release.
Apathy symptoms are common in older people without dementia. And the fact that participants in our study had apathy without depression should turn our attention to how apathy alone could indicate brain disease.
As published April 16 on the website of the journal Neurology, Launers team used brain volume as a measure of accelerated brain aging. Brain volume losses occur during normal aging, but the researchers noted that larger amounts of brain volume loss among the study population could indicate brain diseases.
For the study, 4,354 people without dementia and with an average age of 76 underwent an MRI scan. They were asked questions that measure apathy symptoms, which include lack of interest, lack of emotion, dropping activities and interests, preferring to stay at home and having a lack of energy.
The study found that people with two or more apathy symptoms had 1.4% smaller gray matter volume and 1.6% less white matter volume than those who had less than two symptoms of apathy. Excluding people with depression symptoms did not change the results.
Gray matter is where learning takes place and memories are stored in the brain. White matter acts as the communication cables that connect different parts of the brain.
If these findings are confirmed, identifying people with apathy earlier may be one way to target an at-risk group, Launer said.
Neurology is the medical journal of the American Academy of Neurology. Study abstract: http://bit.ly/1ncBnNL